Vaccine-preventable diseases kill thousands of adults each year in New York City. Influenza and pneumonia together remain the third-leading cause of death. While immunizations are one of the most effective ways to reduce morbidity and mortality from vaccine-preventable diseases, vaccine coverage among adults in the City and across the United States remains low. Health care providers play a critical role in ensuring their patients are vaccinated. This toolkit offers evidence-based strategies and tools to improve adult vaccine coverage at the facility, practice and pharmacy level.