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Forensic Toxicology
Toxicology Technical Manuals
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Manuals effective prior to April 1st, 2023
Toxicology Technical Manuals
Management and Administration
- The Forensic Toxicology Laboratory Mission Statement
- Access to the Forensic Toxicology Laboratory
- Standard Operating Procedures Manual
- Analytical Testing Guidelines (Post Mortem)
- Analytical Testing Guidelines (Human Performance)
- Routinely Tested Analytes
- Case Information and Results
- Final Toxicology Report
- Confidentiality of Case Information and Results
- Personnel Training Criteria
- Continuing Education
- Continuing Education Annual Submission Form
- Notification Guidelines in Cases of Laboratory Error or Misconduct by Laboratory Personnel
- Scientific Working Group for Forensic Toxicology (SWGTOX) – Standard for Developing a Guide and Code of Professional Conduct in Forensic Toxicology
Specimen Management
- Post Mortem (OCME) Specimens
- Human Performance (Non OCME) Specimens
- Computer Assisted Toxicology Specimen Discard – Post Mortem Specimens
- Specimen Send Out to Reference Laboratory Guidelines
Quality Assurance and Quality Control
- Quality Assurance and Quality Control
- Quality Control Summary
- Calibration Curves
- Method Validation
- Method Validation Criteria
- Data Review and Reporting
- Proficiency Testing
- American Board of Forensic Toxicology (ABFT) - Guidelines for Performing Corrective Action for Deviations in Proficiency Test Results
- Proficiency Survey Corrective Action Form
- Pipette Calibration Procedure
- Scientific Working Group for Forensic Toxicology (SWGTOX) – Standard Practices for Method Validation in Forensic Toxicology
- Internal Audit Procedure
- Non-Conforming Work Procedure
Immunoassays
- Screening for Drugs of Abuse in Urine, Whole Blood, Serum and Vitreous Humor by Enzyme-Linked Immunosorbent Assay on the Dynex DSX Microtitter Plate Analyzer
- Preparation of Quality Control for Enzyme-Linked Immunosorbent Assay in Whole Blood, Serum and Vitreous Humor
- Preparation of Quality Control for Enzyme-Linked Immunosorbent Assay in Urine
Head Space Gas Chromatography
- Ethanol, Methanol, 2-Propanol and Acetone by Automated Head Space Analysis
- Volatiles Analysis by GCMS Head Space Analysis
- Analysis of Miscellaneous Volatile Compounds by Head Space Chromatography
Comprehensive Screening by GCMS and NPD
Gas Chromatography Mass Spectrometry
- Sympathomimetic Amines by Solid Phase Extraction and Gas Chromatography / Mass Spectrometry (Full Scan)
- Sympathomimetic Amines by Solid Phase Extraction and Gas Chromatography / Mass Spectrometry (Selective Ion Monitoring)
- Benzodiazepines by Solid Phase Extraction and Gas Chromatography / Mass Spectrometry (Selected Ion Monitoring)
- Carisoprodol, Meporobamate, Topiramate by Solid Phase Extraction and Gas Chromatography / Mass Spectrometry (Selected Ion Monitoring)
- Fentanyl by Solid Phase Extraction and Gas Chromatography / Mass Spectrometry (Selected Ion Monitoring)
- Gamma-Hydroxybutyrate by Solid Phase Extraction and Gas Chromatography / Mass Spectrometry (Selected Ion Monitoring)
- Ehylene Glycol and Propylene Glycol by Gas Chromatography / Mass Spectrometry
- Nicotine and Cotinine by Solid Phase Extraction and Gas Chromatography / Mass Spectrometry (Selected Ion Monitoring)
- Cocaine, Ethylbenzoylecgonine, Benzoylecgonine, Codeine, 6-MAM and Morphine by Gas Chromatography / Mass Spectrometry
- Hydrolysis Specimens for Solid Phase Extraction
- GC / Mass Spectrometry Tuning (Autotune)
- GC / MS Maintenance
- Tramadol, O-desmethyltramadol, N-desmethyltramadol by Solid Phase Extraction with GCMS/NPD Analysis
- Levetiracetam by Solid Phase Extraction and Gas Chromatography/Mass Spectrometry (Selective Ion Monitoring)
- Methadone & EDDP by Liquid/Liquid Extraction and Gas Chromatography/Mass Spectrometry (Selective Ion Monitoring)
Gas Chromatography NPD
- Basic Drugs Quantitation by NPD Gas Chromatography
- Basic Analytes Calibrators and Controls
- Cyanide by NPD Gas Chromatography
- GC-NPD Derivatives with TFAA
- NPD Gas Chromatography
- Drugs Extracted by SPE with GC-NPD Analysis (Lamotrigine, Ondansetron, Cetirizine, Clonidine, Clopidogrel)
- Metoclopramide, Trimethoprim, Ticlopidine, Tramadol, Tramadol Metabolites (O-Desmethyl and N-Desmethyl Tramadol), Bromazepam, Venlafaxine and O-Desmethyl Venlafaxine by SPE and GC-NPD Analysis
- GC Routine Maintenance Agilent 6890
- Troubleshooting of Agilent Gas Chromatographs
High Performance Liquid Chromatography
- Acetaminophen, Salicylates, Theophylline, Caffeine by Solid Phase Extraction and High Performance Liquid Chromatography
- Barbiturates, Phenytoin and Carbamazepine by Solid Phase Extraction and High Performance Liquid Chromatography
- Ibuprofen, Naproxen, Warfarin by High Performance Liquid Chromatography
- Ibuprofen, Naproxen, Warfarin by Solid Phase Extraction and High Performance Liquid Chromatography
- Preparation of Quality Control for HPLC Assays
- HPLC Sequence Set Up using Easy Sequence
- HPLC Maintenance
- HPLC Troubleshooting
Liquid Chromatography Gas Spectrometry
- Benzoylecgonine, Cocaine, EBE, Morphine, Codeine, 6-MAM, Oxycodone, Ocymorphone, Hydrocodone and Hydromorphone by LCMS Analysis
- LCMS Tuning (Autotime / Checktune)
Miscellaneous Procedures
- Acetaminophen (Color Test)
- Salicylates (Color Test)
- Preparation of Quality Control for Color Tests
- Ethchlorvynol (Color Test)
- Halogen Hydrocarbons (Color Test)
- Cyanide (Color Test)
- Carbon Monoxide by Microdiffusion (qualitative)
- Heavy Metals Antimony, Arsenic, Bismuth, Mercury by Reinsch Test
- Vitreous Humor Chemistries
- 7-aminoclonazepam, Clonazepam (Panel 1) by Solid Phase Extraction and Liquid Chromatography/Mass Spectrometry (Selected Ion Monitoring) in Blood or Serum
- Nordiazepam (Panel 2) by Solid Phase Extraction and Liquid Chromatography/Mass Spectrometry (Selected Ion Monitoring) in Blood or Serum
- Clenbuterol by Liquid Chromatography/Mass Spectrometry